产品名称

Phospho-Cyclin E1 (T77) Antibody

产品货号

ABB5816

其他名称

CCNE; Ccne1; cyclin E variant ex5del; cyclin E variant ex7del; Cyclin E1; Cyclin Es; Cyclin Et; G1/S specific cyclin E; G1/S-specific cyclin-E1;

Gene ID

Human:P24864    

SwissPro

Human:http://www.uniprot.org/uniprot/P24864    

宿主种属

Rabbit IgG

应用范围

WB IHC ICC/IF

稀释比例

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

反应种属

Human

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human Cyclin E1

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20

背景资料

48kDa

产品概述

Cyclin E1 and cyclin E2 can associate with and activate CDK2. Upon DNA damage, upregulation/activation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. Cyclin E1 is phosphorylated at multiple sit