产品名称

ADAM17 Antibody

产品货号

ABB6698

其他名称

CD156b; ADAM17; CSVP; TACE;

Gene ID

Human:P78536    

SwissPro

Human:http://www.uniprot.org/uniprot/P78536    

宿主种属

Rabbit IgG

应用范围

WB ICC/IF IP FC

稀释比例

WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50 FC 1:100

反应种属

Human Mouse Rat

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human ADAM17

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20

背景资料

100kDa

产品概述

TACE is responsible for the shedding of EGFR ligands such as amphiregulin and TNF-α. Some tumors have hyperactivated EGFR due to upregulated TNF-α production and upregulated TACE, making TACE a potential target for drug development. TACE activates Notch i