产品名称

PRAS40 Antibody

产品货号

ABB6904

其他名称

40 kDa proline rich AKT substrate; AKT1 S1; AKT1 substrate 1 (proline rich); AKT1S1; Lobe; PRAS40; Proline rich akt substrate;

Gene ID

Human:Q96B36    

SwissPro

Human:http://www.uniprot.org/uniprot/Q96B36    

宿主种属

Rabbit IgG

应用范围

WB IHC IP FC

稀释比例

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50 FC 1:50

反应种属

Human Mouse

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human PRAS40

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20

背景资料

40kDa

产品概述

PRAS40 interacts with Raptor in mTOR complex 1 (mTORC1) in insulin-deprived cells and inhibits the activation of the mTORC1 pathway mediated by the cell cycle protein Rheb. Phosphorylation of PRAS40 by Akt at Thr246 relieves PRAS40 inhibition of mTORC1. m