产品名称

Hamartin Antibody

产品货号

ABB8013

其他名称

Hamartin; kiaa0243; LAM; TSC; Tsc1; Tuberous sclerosis 1;

Gene ID

Human:Q92574    

SwissPro

Human:http://www.uniprot.org/uniprot/Q92574    

宿主种属

Rabbit IgG

应用范围

WB IHC ICC/IF FC

稀释比例

WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:200

反应种属

Human

克隆性

Monoclonal

免疫原

A synthesized peptide derived from human Hamartin

保存液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

纯化方式

Affinity-chromatography

保存条件

-20

背景资料

150kDa

产品概述

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor.